Astaxanthin (3,3'-dihydroxy-beta, beta-carotene-4,4'-dione) ke carotenoid, e arotsoeng e le lutein, e fumanoang mefuteng e mengata ea likokoana-hloko le liphoofolong tsa leoatleng, 'me qalong e ne e arotsoe ho li-lobster ke Kuhn le Sorensen. Ke 'mala o qhibilihang mafura o bonahalang o le lamunu ho isa bofubelung bo tebileng 'me ha o na vithamine A e sebetsang hantle' meleng oa motho.
Mehloli ea tlhaho ea astaxanthin e kenyelletsa bolele, tomoso, salmon, trout, krill le crayfish. Astaxanthin ea khoebo e nkiloe haholo-holo ho tomoso ea Fife, bolele bo bofubelu le tlhahiso ea lik'hemik'hale. E 'ngoe ea mehloli e metle ka ho fetisisa ea astaxanthin ea tlhaho ke chlorella e khubelu e fepuoang ke pula, e nang le astaxanthin e ka bang 3.8% (ka boima bo omileng), 'me salmon ea naha le eona ke mehloli e metle ea astaxanthin. Tlhahiso ea maiketsetso e ntse e le mohloli o moholo oa astaxanthin ka lebaka la litšenyehelo tse phahameng tsa temo e kholo ea Rhodococcus rainieri. Mosebetsi oa baeloji oa astaxanthin e hlahisitsoeng ka maiketsetso ke 50% feela ea astaxanthin ea tlhaho.
Astaxanthin e teng e le li-stereoisomers, li-isomers tsa geometri, libopeho tse lokolohileng le tse tiisitsoeng, 'me li-stereoisomers (3S,3'S) le (3R,3'R) ke tsona tse ngata ka ho fetisisa tlhahong. Rhodococcus rainieri e hlahisa (3S,3'S)-isomer 'me tomoso ea Fife e hlahisa (3R,3'R)-isomer.
Astaxanthin, mocheso oa motsotsoana
Astaxanthin ke motsoako o hlahelletseng lijong tse sebetsang Japane. Lipalopalo tsa FTA mabapi le liphatlalatso tsa lijo tse sebetsang Japane ka 2022 li fumane hore astaxanthin e behiloe boemong ba 7 har'a metsoako e 10 e holimo mabapi le makhetlo a sebelisoang, 'me e ne e sebelisoa haholo-holo mafapheng a bophelo bo botle a tlhokomelo ea letlalo, tlhokomelo ea mahlo, phomolo ea mokhathala le ntlafatso ea ts'ebetso ea kelello.
Likhau tsa 2022 le 2023 tsa Lisebelisoa tsa Phepo ea Asia,Bophelo ba Justgood motsoako oa tlhaho oa astaxanthin o ile oa ananeloa e le motsoako o motle ka ho fetisisa oa selemo ka lilemo tse peli tse latellanang, motsoako o motle ka ho fetisisa pina ea ts'ebetso ea kelello ka 2022, le motsoako o motle ka ho fetisisa pina ea botle ba molomo ka 2023. Ho phaella moo, motsoako ona o ile oa thathamisoa lethathamong la Likhau tsa Asian Nutritional Ingredients - Healthy Aging ka 2024.
Lilemong tsa morao tjena, lipatlisiso tsa thuto mabapi le astaxanthin le tsona li qalile ho futhumala. Ho ea ka lintlha tsa PubMed, khale koana ka 1948, ho bile le lithuto mabapi le astaxanthin, empa tlhokomelo e bile tlase, ho tloha ka 2011, litsebi li ile tsa qala ho tsepamisa maikutlo ho astaxanthin, ka likhatiso tse fetang 100 ka selemo, le tse fetang 200 ka 2017, tse fetang 300 ka 2020, le tse fetang 400 ka 2021.
Mohloli oa setšoantšo: PubMed
Mabapi le 'maraka, ho latela temohisiso ea 'maraka oa Future, boholo ba 'maraka oa lefats'e oa astaxanthin bo hakanngoa ho ba USD 273.2 milione ka 2024 mme ho lebelletsoe hore bo tla fihla ho USD 665.0 milione ka 2034, ho CAGR ea 9.3% nakong ea nako ea ponelopele (2024-2034).
Bokhoni bo phahameng ba antioxidant
Sebopeho se ikhethang sa Astaxanthin se e fa bokgoni bo babatsehang ba ho thibela dikokwana-hloko. Astaxanthin e na le dibonto tse pedi tse kopantsweng, dihlopha tsa hydroxyl le ketone, mme e na le lipophilic le hydrophilic. Bonto e pedi e kopantsweng bohareng ba motsoako e fana ka dielektrone mme e arabela le di-free radical ho di fetola dihlahiswa tse tsitsitseng haholoanyane le ho fedisa diketso tsa ketane ya free radical dipheding tse fapaneng. Tshebetso ya yona ya baeloji e feta ya di-antioxidants tse ding ka lebaka la bokgoni ba yona ba ho hokela lera la sele ho tloha kahare ho ya kantle.
Sebaka sa astaxanthin le li-antioxidants tse ling ka har'a lera la sele
Astaxanthin e na le ts'ebetso e kholo ea antioxidant eseng feela ka ho tlosa li-free radical ka kotloloho, empa hape le ka ho kenya tšebetsong sistimi ea ts'ireletso ea antioxidant ea sele ka ho laola tsela ea nuclear factor erythroid 2-related factor (Nrf2). Astaxanthin e thibela ho thehoa ha ROS mme e laola tlhahiso ea li-enzyme tse arabelang khatello ea oxidative, joalo ka heme oxygenase-1 (HO-1), e leng letšoao la khatello ea oxidative.HO-1 e laoloa ke mefuta e fapaneng ea lintlha tsa transcription tse amang khatello ea maikutlo, ho kenyeletsoa le Nrf2, e tlamang ho likarolo tse arabelang antioxidant sebakeng sa promoter sa li-enzyme tsa metabolism ea detoxification.
Mefuta e felletseng ea melemo le lits'ebetso tsa astaxanthin
1) Ntlafatso ea ts'ebetso ea kelello
Lithuto tse ngata li tiisitse hore astaxanthin e ka liehisa kapa ea ntlafatsa likhaello tsa kelello tse amanang le botsofali bo tloaelehileng kapa ea fokotsa pathophysiology ea mafu a fapaneng a methapo ea kutlo. Astaxanthin e ka tšela mokoallo oa mali le boko, 'me lithuto li bontšitse hore astaxanthin ea lijo e bokellana ka har'a hippocampus le cerebral cortex ea boko ba rat ka mor'a ho e ja hang le khafetsa, e leng se ka amang tlhokomelo le ntlafatso ea ts'ebetso ea kelello. Astaxanthin e khothalletsa tsosoloso ea lisele tsa methapo 'me e eketsa polelo ea liphatsa tsa lefutso ea protheine ea glial fibrillary acidic (GFAP), protheine e amanang le microtubule 2 (MAP-2), neurotrophic factor e nkiloeng bokong (BDNF), le protheine e amanang le kholo 43 (GAP-43), liprotheine tse amehang ho hlaphoheloeng ha boko.
Li-capsule tsa Justgood Health Astaxanthin, tse nang le Cytisine le Astaxanthin tse tsoang ho Red Algae Rainforest, lia sebelisana ho ntlafatsa ts'ebetso ea boko ea kelello.
2) Tšireletso ea Mahlo
Astaxanthin e na le ts'ebetso ea antioxidant e thibelang limolek'hule tse se nang oksijene le ho fana ka tšireletso bakeng sa mahlo. Astaxanthin e sebetsa hammoho le li-carotenoid tse ling tse tšehetsang bophelo bo botle ba mahlo, haholo-holo lutein le zeaxanthin. Ho phaella moo, astaxanthin e eketsa sekhahla sa phallo ea mali leihlong, e leng se lumellang mali ho khutlisetsa oksijene ho retina le lisele tsa mahlo. Lithuto li bontšitse hore astaxanthin, hammoho le li-carotenoid tse ling, e sireletsa mahlo tšenyong ho pholletsa le mahlaseli a letsatsi. Ho phaella moo, astaxanthin e thusa ho imolla ho se phutholohe ha mahlo le mokhathala oa pono.
Li-Softgel tsa Justgood Health Blue Light Protection, Lisebelisoa tsa bohlokoa: lutein, zeaxanthin, astaxanthin.
3) Tlhokomelo ea Letlalo
Khatello ea oxidative ke sesosa sa bohlokoa sa botsofali ba letlalo la motho le tšenyo ea letlalo. Mokhoa oa botsofali ba ka hare (ka tatellano ea liketsahalo) le ba kantle (bo bobebe) ke tlhahiso ea ROS, ka hare ho metabolism ea oxidative, le ka ntle ho eona ka ho pepesehela mahlaseli a letsatsi a ultraviolet (UV). Liketsahalo tsa oxidative botsofaling ba letlalo li kenyelletsa tšenyo ea DNA, likarabo tsa ho ruruha, phokotso ea li-antioxidants, le tlhahiso ea matrix metalloproteinases (MMPs) tse senyang collagen le elastin ka har'a dermis.
Astaxanthin e ka thibela ka katleho tšenyo ea oxidative e bakoang ke li-free radical le ho kenngoa ha MMP-1 letlalong kamora ho pepesehela UV. Lithuto li bontšitse hore astaxanthin e tsoang ho Erythrocystis rainbowensis e ka eketsa collagen ka ho thibela tlhahiso ea MMP-1 le MMP-3 ho li-fibroblast tsa letlalo la motho. Ho phaella moo, astaxanthin e fokolitse tšenyo ea DNA e bakoang ke UV le ho eketsa tokiso ea DNA liseleng tse pepesehetseng mahlaseli a UV.
Hona jwale Justgood Health e ntse e etsa dithuto tse mmalwa, ho kenyeletswa le dipeba tse se nang moriri le diteko tsa batho, tseo kaofela di bontshitseng hore astaxanthin e fokotsa tshenyo ya UV dikarolong tse tebileng tsa letlalo, e leng se bakang ponahalo ya matshwao a botsofadi ba letlalo, jwalo ka ho oma, letlalo le tetebelang le makukuno.
4) Phepo ea lipapali
Astaxanthin e ka potlakisa tokiso ea kamora boikoetliso. Ha batho ba ikoetlisa kapa ba ikoetlisa, 'mele o hlahisa ROS e ngata, eo, haeba e sa tlosoe ka nako, e ka senyang mesifa le ho ama ho hlaphoheloa ha' mele, ha ts'ebetso e matla ea astaxanthin ea antioxidant e ka tlosa ROS ka nako le ho lokisa mesifa e senyehileng kapele.
Justgood Health e hlahisa Astaxanthin Complex ea eona e ncha, motsoako o mongata oa magnesium glycerophosphate, vithamine B6 (pyridoxine), le astaxanthin e fokotsang bohloko ba mesifa le mokhathala ka mor'a boikoetliso. Mokhoa ona o shebane le Whole Algae Complex ea Justgood Health, e fanang ka astaxanthin ea tlhaho e sa sireletseng mesifa feela tšenyong ea oxidative, empa hape e ntlafatsang ts'ebetso ea mesifa le ho ntlafatsa ts'ebetso ea lipapali.
5) Bophelo bo Botle ba Pelo le Methapo ea Methapo
Khatello ea oxidative le ho ruruha li khetholla pathophysiology ea lefu la pelo le methapo ea mali le atherosclerotic. Tšebetso e ntle ea antioxidant ea astaxanthin e ka thibela le ho ntlafatsa atherosclerosis.
Li-softgel tsa Justgood Health Triple Strength Natural Astaxanthin li thusa ho boloka bophelo bo botle ba pelo le methapo ea mali ka ho sebelisa astaxanthin ea tlhaho e tsoang ho algae e khubelu ea mookoli, metsoako ea mantlha ea eona e kenyelletsa astaxanthin, oli ea kokonate ea organic virgin le li-tocopherols tsa tlhaho.
6) Taolo ea 'mele oa ho itšireletsa mafung
Lisele tsa sesole sa 'mele li na le kutlo e matla haholo tšenyong ea li-free radical. Astaxanthin e sireletsa tšireletso ea sesole sa 'mele ka ho thibela tšenyo ea li-free radical. Phuputso e fumane hore astaxanthin liseleng tsa motho ho hlahisa li-immunoglobulins, 'meleng oa motho ho tlatselletsoa ha astaxanthin ka libeke tse 8, maemo a astaxanthin maling a eketsehile, lisele tsa T le lisele tsa B li eketsehile, tšenyo ea DNA ea fokotseha, protheine ea C-reactive e fokotsehile haholo.
Li-softgel tsa Astaxanthin, astaxanthin e tala, li sebelisa khanya ea letsatsi ea tlhaho, metsi a sefiloeng ke lava le matla a letsatsi ho hlahisa astaxanthin e hloekileng le e phetseng hantle, e ka thusang ho ntlafatsa sesole sa 'mele, ho sireletsa pono le bophelo bo botle ba manonyeletso.
7) Fokotsa mokhathala
Phuputso ea libeke tse 4 e sa reroang, e foufetseng habeli, e laoloang ke placebo, e nang le mekhoa e 'meli ea ho kopanya lisele e fumane hore astaxanthin e khothalletsa ho hlaphoheloa mokhathaleng oa kelello o bakoang ke pono (VDT), e fokotsa maemo a phahameng a phosphatidylcholine hydroperoxide (PCOOH) plasma nakong ea boikoetliso ba kelello le ba 'mele. Lebaka e ka ba ts'ebetso ea antioxidant le mokhoa oa ho thibela ho ruruha oa astaxanthin.
8) Tšireletso ea sebete
Astaxanthin e na le litlamorao tse thibelang le tse ntlafatsang mathata a bophelo bo botle a kang fibrosis ea sebete, kotsi ea ischemia-reperfusion ea sebete, le NAFLD. Astaxanthin e ka laola litsela tse fapaneng tsa ho supa matšoao, joalo ka ho fokotsa ts'ebetso ea JNK le ERK-1 ho ntlafatsa ho hanyetsa insulin sebeteng, ho thibela tlhahiso ea PPAR-γ ho fokotsa tlhahiso ea mafura sebeteng, le ho fokotsa tlhahiso ea TGF-β1/Smad3 ho thibela ts'ebetso ea HSCs le fibrosis ea sebete.
Boemo ba melaoana naheng ka 'ngoe
Chaena,astaxanthin ho tsoa mohloling oa mookoli o mofubelu oa bolele bo ka sebelisoa e le motsoako o mocha oa lijo lijong tse akaretsang (ntle le lijo tsa masea), ho phaella moo, United States, Canada le Japane le tsona li lumella astaxanthin ho sebelisoa lijong.
Nako ea poso: Tshitwe-05-2024