Astaxanthin (3,3'-dihydroxy-beta,beta-carotene-4,4'-dione) ke carotenoid, e khetholloang e le lutein, e fumanoang mefuteng e mengata ea likokoana-hloko le liphoofolo tsa leoatleng, 'me qalong e ne e arohane le lobster ke Kuhn le Sorensen. Ke pigment e qhibilihang ka mafura e hlahang 'mala oa lamunu ho isa bofubelu bo tebileng' me ha e na vithamine A e sebetsang hantle 'meleng oa motho.
Mehloli ea tlhaho ea astaxanthin e kenyelletsa algae, yeast, salmon, trout, krill le crayfish. Astaxanthin ea khoebo e tsoa haholo tomoso ea Fife, algae e khubelu le motsoako oa lik'hemik'hale. E 'ngoe ea mehloli e metle ka ho fetisisa ea astaxanthin ea tlhaho ke chlorella e khubelu ea pula, e nang le litaba tsa astaxanthin tse ka bang 3.8% (ka boima bo omileng), le salmon e hlaha le eona ke mehloli e metle ea astaxanthin. Tlhahiso ea maiketsetso e ntse e le mohloli o ka sehloohong oa astaxanthin ka lebaka la litšenyehelo tse phahameng tsa temo e kholo ea Rhodococcus rainieri. Ts'ebetso ea biological ea astaxanthin e entsoeng ka maiketsetso ke 50% feela ea ea astaxanthin ea tlhaho.
Astaxanthin e teng e le li-stereoisomers, li-isomers tsa geometric, liforomo tse sa lefelloeng le tse tiisitsoeng, tse nang le li-stereoisomers (3S,3'S) le (3R,3'R) e leng tsona tse ngata ka ho fetisisa ka tlhaho. Rhodococcus rainieri e hlahisa (3S,3'S) -isomer le Fife yeast e hlahisa (3R,3'R) -isomer.
Astaxanthin, mocheso oa motsotsoana
Astaxanthin ke motsoako oa linaleli lijong tse sebetsang Japane. Lipalopalo tsa FTA mabapi le liphatlalatso tsa lijo tse sebetsang Japane ka 2022 li fumane hore astaxanthin e behiloe sebakeng sa No. tlhokomelo ea letlalo, tlhokomelo ea mahlo, ho imolla mokhathala, le ntlafatso ea ts'ebetso ea kelello.
Likhaung tsa 2022 le 2023 tsa 2023 tsa Asia Nutritional Ingredients, motsoako oa tlhaho oa astaxanthin oa Justgood Health o ile oa amoheloa e le motsoako o motle ka ho fetisisa oa selemo bakeng sa lilemo tse peli tse latellanang, motsoako o motle ka ho fetisisa oa ts'ebetso ea kelello ka 2022, le motsoako o motle ka ho fetisisa pina ea botle ba molomo. 2023. Ho feta moo, motsoako o ne o thathamisitsoe ho Likhau tsa Asia Nutritional Ingredients - Pina ea Botsofali bo Botle ka 2024.
Lilemong tsa morao tjena, lipatlisiso tsa thuto ka astaxanthin le tsona li qalile ho futhumala. Ho latela lintlha tsa PubMed, ho tloha ka 1948, ho ne ho e-na le lithuto tsa astaxanthin, empa tlhokomelo e ntse e le tlaase, ho qala ka 2011, thuto ea thuto e ile ea qala ho tsepamisa maikutlo ho astaxanthin, ka likhatiso tse fetang 100 ka selemo, le tse fetang 200 ka 2017, ho feta. ho feta 300 ka 2020, le tse fetang 400 ka 2021.
Mohloli oa setšoantšo:PubMed
Mabapi le 'maraka, ho latela leseli la 'maraka oa Bokamoso, boholo ba mmaraka oa astaxanthin bo hakanngoa hore e ka ba $ 273.2 milione ka 2024 mme ho hakanngoa hore e tla fihla ho $ 665.0 milione ka 2034, ho CAGR ea 9.3% nakong ea kemiso (2024-2034) ).
Matla a phahameng a antioxidant
Sebopeho se ikhethileng sa Astaxanthin se e fa matla a matla a antioxidant. Astaxanthin e na le li-conjugated bond tse peli, hydroxyl le lihlopha tsa ketone, 'me ke lipophilic le hydrophilic. The conjugated double bond bohareng ba motsoako o fana ka lielektrone le ho sebetsana le li-radicals tsa mahala ho li fetola lihlahisoa tse tsitsitseng haholoanyane le ho felisa liketso tsa ketane ea mahala ho lintho tse fapaneng. Ts'ebetso ea eona ea tlhaho e phahametse ea li-antioxidants tse ling ka lebaka la bokhoni ba eona ba ho hokahana le lera la lisele ho tsoa kahare.
Sebaka sa astaxanthin le li-antioxidants tse ling ka har'a membrane ea lisele
Astaxanthin e fana ka ts'ebetso ea bohlokoa ea li-antioxidant eseng feela ka ho hloekisoa ka ho toba ha li-radicals tsa mahala, empa hape ka ho kenya ts'ebetso ea cellular antioxidant system ka ho laola tsela ea nyutlelie ea erythroid 2-related factor (Nrf2). Astaxanthin e thibela ho thehoa ha ROS 'me e laola polelo ea li-enzyme tse arabelang khatello ea kelello, tse kang heme oxygenase-1 (HO-1), e leng letšoao la khatello ea kelello ea oxidative.HO-1 e laoloa ke mefuta e sa tšoaneng ea ho ngoloa ha khatello ea kelello. lintlha, ho kenyelletsa le Nrf2, e tlamang ho likarolo tsa antioxidant tse arabelang sebakeng se khothalletsang li-enzyme tsa detoxification metabolism.
Lethathamo le felletseng la melemo le lits'ebetso tsa astaxanthin
1) Ntlafatso ea ts'ebetso ea kelello
Lithuto tse ngata li netefalitse hore astaxanthin e ka liehisa kapa ea ntlafatsa bofokoli ba kelello bo amanang le botsofali bo tloaelehileng kapa ea thefula pathophysiology ea mafu a fapaneng a neurodegenerative. Astaxanthin e ka tšela mokoallo oa mali-bokong, 'me liphuputso li bontšitse hore astaxanthin ea lijo e bokellana hippocampus le cerebral cortex ea boko ba rat ka mor'a ho noa hang-hang le khafetsa, e ka amang tlhokomelo le ntlafatso ea ts'ebetso ea kelello. Astaxanthin e khothalletsa ho tsosolosoa ha lisele tsa methapo le ho eketsa liphatsa tsa lefutso tsa protheine ea glial fibrillary acidic (GFAP), protheine e amanang le microtubule 2 (MAP-2), neurotrophic factor (BDNF) e tsoang bokong (BDNF), le protheine e amanang le kholo ea 43 (GAP-43), liprotheine tse amehang ho foleng ha boko.
Justgood Health Astaxanthin Capsules, e nang le Cytisine le Astaxanthin ho tsoa ho Red Algae Rainforest, li kopanya ho ntlafatsa ts'ebetso ea kelello ea boko.
2) Tšireletso ea Mahlo
Astaxanthin e na le ts'ebetso ea antioxidant e fokotsang limolek'hule tsa mahala tsa oksijene mme e fana ka tšireletso bakeng sa mahlo. Astaxanthin e sebetsa ka tumellano le li-carotenoids tse ling tse tšehetsang bophelo bo botle ba mahlo, haholo lutein le zeaxanthin. Ntle le moo, astaxanthin e eketsa sekhahla sa phallo ea mali mahlong, e lumella mali ho khutlisetsa oksijene ho retina le lisele tsa mahlo. Liphuputso li bonts'itse hore astaxanthin, hammoho le li-carotenoids tse ling, e sireletsa mahlo tšenyo ho pholletsa le mahlaseli a letsatsi. Ntle le moo, astaxanthin e thusa ho imolla ho se phutholohe ha mahlo le mokhathala oa pono.
Justgood Health Blue Light Protection Softgels, Lisebelisoa tsa bohlokoa: lutein, zeaxanthin, astaxanthin.
3) Tlhokomelo ea Letlalo
Khatello ea oxidative ke sesosa sa bohlokoa sa ho tsofala ha letlalo la motho le ho senyeha ha letlalo. Mokhoa oa botsofali ba ka hare (cronological) le extrinsic (light) ke tlhahiso ea ROS, ka tlhaho ka metabolism ea oxidative, le ka ntle ka ho pepesehela mahlaseli a letsatsi a ultraviolet (UV). Liketsahalo tsa oxidative botsofaling ba letlalo li kenyelletsa tšenyo ea DNA, likarabo tsa ho ruruha, phokotso ea li-antioxidants, le tlhahiso ea matrix metalloproteinases (MMPs) e senyang collagen le elastin ka dermis.
Astaxanthin e ka thibela ka nepo tšenyo ea oxidative ea radical-induced oxidative le ho kenngoa ha MMP-1 letlalong ka mor'a ho pepesehela UV. Boithuto bo bontšitse hore astaxanthin e tsoang ho Erythrocystis rainbowensis e ka eketsa litaba tsa collagen ka ho thibela polelo ea MMP-1 le MMP-3 ho dermal fibroblasts. Ntle le moo, astaxanthin e nyenyefalitse ts'enyo ea DNA e bakiloeng ke UV mme ea eketsa tokiso ea DNA liseleng tse pepeselitsoeng mahlaseli a UV.
Hona joale Justgood Health e ntse e etsa lithuto tse 'maloa, ho kenyelletsa le likhoto tse se nang moriri le liteko tsa batho, tseo kaofela li bonts'itseng hore astaxanthin e fokotsa tšenyo ea UV ho likarolo tse tebileng tsa letlalo, tse bakang ponahalo ea matšoao a botsofali ba letlalo, joalo ka ho omella, ho putlama ha letlalo. wrinkles.
4) Phepo ea lipapali
Astaxanthin e ka potlakisa tokiso ea kamora ho ikoetlisa. Ha batho ba ikoetlisa kapa ba ikoetlisa, 'mele o hlahisa ROS e ngata, eo, haeba e sa tlosoe ka nako, e ka senya mesifa le ho ama ho hlaphoheloa ha' mele, ha astaxanthin e matla ea antioxidant e ka tlosa ROS ka nako le ho lokisa mesifa e senyehileng ka potlako.
Justgood Health e hlahisa Astaxanthin Complex ea eona e ncha, motsoako o mongata oa magnesium glycerophosphate, vithamine B6 (pyridoxine), le astaxanthin e fokotsang bohloko ba mesifa le mokhathala ka mor'a ho ikoetlisa. Foromo ena e thehiloe ho Justgood Health's Whole Algae Complex, e fanang ka astaxanthin ea tlhaho e sa sireletseng feela mesifa ho tsoa tšenyo ea oxidative, empa hape e ntlafatsa ts'ebetso ea mesifa le ho ntlafatsa ts'ebetso ea liatleletiki.
5) Bophelo bo botle ba pelo
Khatello ea oxidative le ho ruruha li bonts'a pathophysiology ea atherosclerotic cardiovascular disease. Ts'ebetso e ntlehali ea antioxidant ea astaxanthin e ka thibela le ho ntlafatsa atherosclerosis.
Justgood Health Triple Strength Natural Astaxanthin Softgels e thusa ho boloka bophelo bo botle ba pelo ka ho sebelisa astaxanthin ea tlhaho e tsoang ho algae e khubelu ea mookoli, metsoako ea eona e ka sehloohong e kenyelletsang astaxanthin, oli ea kokonate ea moroetsana le li-tocopherols tsa tlhaho.
6) Taolo ea 'mele oa ho itšireletsa mafung
Lisele tsa tsamaiso ea 'mele ea ho itšireletsa mafung li na le kutloelo-bohloko haholo ho senyeha ha radical mahala. Astaxanthin e sireletsa ts'ireletso ea sesole sa 'mele ka ho thibela tšenyo e matla ea mahala. Phuputso e fumane hore astaxanthin liseleng tsa motho ho hlahisa li-immunoglobulins, 'meleng oa motho astaxanthin tlatsetso bakeng sa libeke tsa 8, litekanyetso tsa astaxanthin maling li ile tsa eketseha, lisele tsa T le lisele tsa B li eketseha, tšenyo ea DNA e fokotsehile, protheine ea C-reactive e fokotsehile haholo.
Li-softgels tsa Astaxanthin, astaxanthin e tala, li sebelisa khanya ea letsatsi ea tlhaho, metsi a tlhotliloeng ka seretse se chesang le matla a letsatsi ho hlahisa astaxanthin e hloekileng le e phetseng hantle, e ka thusang ho matlafatsa sesole sa 'mele, ho sireletsa pono le bophelo bo botle bo kopaneng.
7) Fokotsa Mokhathala
Phuputso ea libeke tse 4 e sa sebetseng, e foufetseng habeli, e laoloang ke placebo, ea litsela tse peli e fumane hore astaxanthin e khothalelitse ho hlaphoheloa ho tloha mokhathala oa kelello o bakoang ke VDT, ho fokotsa maemo a phahameng a plasma phosphatidylcholine hydroperoxide (PCOOH) nakong ea kelello le 'mele. mosebetsi. Lebaka e kanna ea ba ts'ebetso ea antioxidant le mochini o thibelang ho ruruha oa astaxanthin.
8) Tšireletso ea sebete
Astaxanthin e na le litlamorao le tse matlafatsang mathateng a bophelo bo botle joalo ka sebete fibrosis, sebete sa ischemia-reperfusion kotsi, le NAFLD. Astaxanthin e ka laola litsela tse fapa-fapaneng tsa lipontšo, tse kang ho fokotsa mosebetsi oa JNK le ERK-1 ho ntlafatsa ho hanyetsa insulin ea sebete, ho thibela polelo ea PPAR-γ ho fokotsa tlhahiso ea mafura a sebete, le ho fokotsa TGF-β1 / Smad3 polelo e thibelang ts'ebetso ea HSC le sebete sa fibrosis.
Boemo ba melaoana naheng ka 'ngoe
Chaena, astaxanthin e tsoang mohloling oa algae e khubelu ea mookoli e ka sebelisoa e le motsoako o mocha oa lijo lijong tse tloaelehileng (ntle le lijo tsa bana), ho phaella moo, United States, Canada le Japane le tsona li lumella astaxanthin hore e sebelisoe lijong .
Nako ea poso: Dec-05-2024