Ho Fetola Maikutlo a Bareki Mabapi le Botsofali

Maikutlo a bareki mabapi le botsofali a ntse a fetoha. Ho ea ka tlaleho ea mekhoa ea bareki eaMoreki e MochaleMotse-moholo o lekanang, Maamerika a mangata ha a shebane feela le ho phela nako e telele empa hape le ho phela bophelo bo botle.

Phuputso ea 2024 e entsoeng ke McKinsey e senotse hore selemong se fetileng, 70% ea bareki ba US le UK (le 85% Chaena) ba rekile lihlahisoa le lits'ebeletso tse ling tse tšehetsang botsofali bo phetseng hantle le bophelo bo bolelele ha li bapisoa le lilemo tse fetileng. Phetoho ena e bonts'a takatso e ntseng e hola ea bareki ea ho laola bophelo ba bona haholoanyane.

Ho phaella moo,Koranta ea Khoebo ea Phepo e Nepahetseng(NBJ) Tlaleho ea Nako e Telele ea 2024 e bontša hore ho tloha ka 2022, kholo ea thekiso sehlopheng sa botsofali bo phetseng hantle e 'nile ea feta' maraka o pharaletseng oa li-supplement. Ka 2023, indasteri eohle ea li-supplement e holile ka 4.4%, ha sehlopha sa botsofali bo phetseng hantle se fihletse sekhahla sa kholo sa 5.5%.NBJmerero eo thekiso eali-supplement tse phetseng hantle tsa botsofali—e akaretsang dihlopha tse fapaneng tse ikgethang ka maemo—e tla feta $1 bilione ka 2024 mme e fihle ho $1.04 bilione ka 2026, e leng se emelang sekgahla sa kgolo sa 7.7%.
1. Matšoenyeho a Bareki Mabapi le Mathata a Bophelo bo Botle a Amanang le Botsofali

AnNBJPhuputso e entsoeng ka 2024 e hlahlobile matšoenyeho a bareki a amanang le botsofali. Litaba tsa bohlokoa li ne li kenyelletsa:

Tahlehelo ea ho tsamaea (28%)
Lefu la Alzheimer kapa dementia (23%)
Tahlehelo ea pono (23%)
Tahlehelo ea boipuso (19%)
Mathata a bophelo bo botle ba maikutlo kapa ba kelello (19%)
Ho senyeha ha mesifa kapa masapo (19%)
Ho hlohlona ha moriri (16%)
Ho hlobaela (16%)

Mohloli oa setšoantšo: NBJ

Ha o sebedisali-supplement, tšireletso ea 'mele (35%) e hlahile e le taba ea bohlokoa ka ho fetisisa ea bophelo bo botle e amanang le botsofali bakeng sa bareki. Lintho tse ling tse tlang pele li ne li kenyelletsa bophelo bo botle ba mala le tšilo ea lijo (28%), bophelo bo botle ba boroko (23%), moriri, letlalo le manala (22%), bophelo bo botle ba mesifa le manonyeletso (21%), bophelo bo botle ba pelo (19%), le boiketlo ba maikutlo (19%).

Mohloli oa setšoantšo: NBJ

2. Lisebelisoa tse Hlano tsa Bohlokoa tsa ho Thibela Botsofali

1. Ergothioneine

Ergothioneine ke amino acid e hlahang ka tlhaho e fumanoeng ka 1909 ke Charles Tanret ha a ntse a ithuta fungus ea ergot. Thiol le thione tautomerism ea eona e ikhethang ho pH ea 'mele e e fa thepa e ikhethang ea antioxidant. Ho ea ka data e tsoang ho Bloomage Biotech, ergothioneine ho Bioyouth™-EGT e bontša ts'ebetso ea ho tlosa li-free radical tsa DPPH ka makhetlo a 14 ho feta glutathione le makhetlo a 30 ho feta coenzyme Q10.

Melemo:

Letlalo:Ergothioneine e sireletsa khahlanong le ho ruruha ho bakoang ke UV, e thibela tšenyo ea DNA, 'me e khothalletsa tlhahiso ea collagen ha ka nako e ts'oanang e fokotsa ho senyeha ha collagen e amanang le UV.
Boko:Ergothioneine e tšehetsa ts'ebetso ea kelello, joalo ka ha ho pakoa ke phuputso ea bongaka e bonts'ang ntlafatso ea kutloisiso kamora libeke tse 12 tsa ho eketsa ergothioneine e tsoang ho li-mushroom.
Boroko:E tšela mokoallo oa mali le boko, e fokotsa ho thehoa ha peroxynitrite, 'me e fokotsa khatello ea maikutlo, e khothalletsa boroko bo betere.

2. Spermidine

Spermidine, karolo ea lelapa la polyamine, e fumanoa haholo linthong tse phelang tse kang libaktheria, li-fungus, limela le liphoofolo. Mehloli e tloaelehileng ea lijo e kenyelletsa koro ea koro, soya le li-mushroom tsa king oyster. Maemo a spermidine a fokotseha ha a ntse a tsofala, 'me liphello tsa eona tsa ho thibela botsofali li amahanngoa le mekhoa e kang ho kenya autophagy, ts'ebetso ea ho thibela ho ruruha, le taolo ea metabolism ea lipid.

Mekhoa:

Autophagy:Spermidine e khothalletsa mekhoa ea ho sebelisa lisele hape, e sebetsana le mafu a amanang le botsofali a amanang le bofokoli ba autophagy.
Anti-ho ruruha: E fokotsa li-cytokine tse bakang ho ruruha ha ka nako e ts'oanang e eketsa lintlha tse thibelang ho ruruha.
Metabolism ea Lipid:Spermidine e susumetsa ka tsela e ntle tlhahiso le polokelo ea lipid, e tšehetsa ho phalla ha lera la sele le ho phela nako e telele.

3. Pyrroloquinoline Quinone (PQQ)

PQQ, quinone coenzyme e qhibilihang ka metsing, e bohlokoa bakeng sa ts'ebetso ea mitochondrial. E sireletsa khahlanong le tšenyo ea mitochondrial e bakoang ke khatello ea oxidative, e khothalletsa biogenesis ea mitochondrial, 'me e ntlafatsa tlhahiso ea methapo ea kholo ea methapo (NGF). Lithuto tsa bongaka li bontša katleho ea eona ho ntlafatseng ts'ebetso ea kelello le phallo ea mali ea libaka ho batho ba hōlileng.

4. Phosphatidylserine (PS)

PS ke anionic phospholipid ka har'a lera la sele ea eukaryotic, e bohlokoa bakeng sa lits'ebetso tse kang ho kenya tšebetsong ha enzyme, apoptosis ea sele, le ts'ebetso ea synaptic. E nkiloe mehloling e kang soya, lintho tse phelang metsing le sonobolomo, PS e tšehetsa litsamaiso tsa neurotransmitter, ho kenyeletsoa acetylcholine le dopamine, tse amanang le bophelo bo botle ba kelello.

Likopo:Tlatsetso ea PS e 'nile ea amahanngoa le ntlafatso maemong a kang Alzheimer's, lefu la Parkinson le khatello ea maikutlo,' me e thusa batho ba nang le ADHD le mathata a autism spectrum.

5. Urolithin A(UA)

UA, e leng metabolite ea ellagitannins e fumanoang lijong tse kang likharenate le linate, e ile ea fumanoa ka 2005. Phuputso e phatlalalitsoe hoBongaka ba Tlhaho(2016) e bontšitse hore UA e khothalletsa mitophagy, e atolosa nako ea bophelo ea li-nematode ka 45%. E kenya tšebetsong litsela tsa mitochondrial autophagy, e hloekisa mitochondria e senyehileng le ho sebetsana le mathata a amanang le botsofali mesifang, methapong ea pelo, 'meleng le bophelong ba letlalo.

Tsela ea mitophagy e kentsoeng tšebetsong ke UA/tšupiso ea mohloli oa setšoantšo 1

Qetello

Ha bareki ba ntse ba beha bophelo bo botle le bophelo bo bolelele pele, tlhoko ea metsoako e mecha ea ho thibela botsofali le li-supplement e ntse e eketseha. Metsoako ea bohlokoa e kang ergothioneine, spermidine, PQQ, PS, le UA e bula tsela bakeng sa litharollo tse reretsoeng matšoenyeho a amanang le botsofali. Metsoako ena e tšehelitsoeng ke saense e totobatsa boitlamo ba indasteri ba ho tšehetsa botsofali bo phetseng hantle le bo matla haholoanyane.